HandBrake Highlights:
BluRay disc structure support. (No decryption support)
Updated Libraries (x264, ffmpeg)
SSA Subtitle support. (Including burn-in)
MP3 audio now supported in MP4 files (Note: Limited Player compatibility)
VOBSUB subtitle now supported in MP4 files (Note: Limited Player compatibility)
Updated Presets for newer devices and better quality
AC3 encoding support.
Many Bug Fixes and other small improvements
Improved DVD Main Feature detection (when using dvdnav)
Universal audio downmix support (all audio types can be downmixed)
Point*to*Point encoding (second or frame start and end times)
Peak framerate option (Capped VFR)
Updated x264 Advanced Panel
Video Quality Slider drops % value and only shows RF for x264
Batch Scan (Scan Multiple files at once. N.B: Does not include multiple VIDEO_TS folders / Image files)
Many Bug fixes
Many Tweaks to improve usability.
Ability to edit queue jobs
Encode Status in GUI. (CLI window is now always hidden)
Improved Auto-Naming for Destination file name.
Drag / Drop Video onto Main Window to scan.

What's New in This Release:
General
Core
Intel QuickSync Video Encode / Decode support.
Windows only currently. We hope to bring this to Linux in the future but not for 0.10.
Hardware Decode support via DXVA (Experimental - Windows Only)
Decoding of some H.264, VC1 and WMV content via the GPU.
Can provide a small improvement on slower hardware. Not suitable for fast CPU's
Choice of Scalers
Lanczos
This is currently Handbrake's default scaler and will remain so.
Bicubic (OpenCL) (Experimental)
Available on the Command Line (All Platforms) and Windows GUI. (Mac / Linux GUI's will come in a later release)
Currently only available in OpenCL form so requires a AMD or Intel GPU supporting OpenCL 1.1 or later. Nvidia GPU's are not currently supported.
When downscaling, up to 5% performance improvement can be achieved. No benefit when not downscaling.
Small loss in quality over the Lanczos scaler.
Denoise
hqdn3d filter now accepts individual settings for both chroma channels (Cr, Cb)
New NlMeans? denoiser. This is very slow, but results are significantly better than hqdn3d.
Presets
Added Windows Phone 8 Preset
Updated Libraries
x264 r2479-dd79a61
Libav v10.1
libbluray 0.5.0
Libavformat is now used for muxing instead of mp4v2 and libmkv
"Large File Size" checkbox has now bee removed for mp4, as the new muxer will transition to 64bit files automatically.
mpeg2dec has also been replaced in favour of using libav
The LibAV AAC encoder is now the default as FAAC has been removed.
This encoder is adequate for most, but until it improves a bit further, we have enabled support for the FDK-AAC encoder also.
This FDK option is a temporary measure until the LibAV encoder improves.
Note that FDK-AAC is much slower and will likely bottleneck the encode process, but will produce better quality audio.
H.265 encoder
Using x265 v1.4
This encoder is still early in it's development, so is missing many H.265 features and optimisations.
Added VP8 Encoder (using libvpx)
Available in MKV files only.
Removed mcdeint deinterlace and decomb modes. This relied on the snow encoder in libav which has been was removed by upstream.
Bug fixes and Misc Improvements

Release 0.10.1 Highlights
Various bug fixes for all platforms and the core engine.
Updated x265 to 1.5 which brings numerous bug fixes and some performance improvements.