This textbook provides the foundation for a course that takes PhD students in empirical accounting research from the very basics of statistics, data analysis, and causal inference up to the point at which they conduct their own research. Starting with foundations in statistics, econometrics, causal inference, and institutional knowledge of accounting and finance, the book moves on to an in-depth coverage of the core papers in capital market research. The latter half of the book examines contemporary approaches to research design and empirical analysis, including natural experiments, instrumental variables, fixed effects, difference-in-differences, regression discontinuity design, propensity-score matching, and machine learning. Readers of the book will develop deep data analysis skills using modern tools. Extensive replication and simulation analyses are included throughout. Key Features: Extensive coverage of empirical accounting research over more than 50 years. Integrated coverage of statistics and econometrics, institutional knowledge, and research design. Numerous replications and a dozen simulation analyses to immerse readers in papers and empirical analysis. All tables and figures in the book can be reproduced by readers using the included code. Easy-to-use templates facilitate hands-on exercises and introduce reproducible research concepts. (Solutions available to instructors.)