It has 16 chapters that focused on the following (chapters 1-16): Bovine Tuberculosis: worldwide picture; Mycobacterium bovis as the causal agent of human tuberculosis: public health implications; economics of bovine tuberculosis: a one health issue; the epidemiology of Mycobacterium bovis infection in cattle; Mycobacterium bovis molecular typing and surveillance; bovine tuberculosis in other domestic species; role of wildlife in the epidemiology of Mycobacterium bovis; molecular virulence mechanisms of Mycobacterium bovis; the pathology and pathogenesis of Mycobacterium bovis infection; innate immune response in bovine tuberculosis; adaptive immunity; immunological diagnosis; biomarkers in the diagnosis of Mycobacterium tuberculosis complex infections; vaccination of domestic and wild animals against tuberculosis; managing bovine tuberculosis: successes and issues; and perspectives on global bovine tuberculosis control.